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Enhancement

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The Goodness of Fragility: On the Prospect of Genetic Technologies Aimed at the Enhancement of Human Capacities

Contemporary issues in Bioethics

In “The Goodness of Fragility: On the Prospect of Genetic Technologies Aimed at the Enhancement of Human Capacities,” Erik Parens encourages us to think about enhancement. He exhorts us to be prudent as we contemplate the use of genetic technologies for the improvement of our own abilities. [1]  He asks, “Will we, in some of our attempts to enhance humans, inadvertently impoverish them by reducing what I will call their fragility” (549). He attempts to “reflect upon what life would be like if we could significantly reduce the change and chance to which we – creatures whose forms are largely determined by the genetic hand dealt us by nature – have hitherto been subject” (549).

Before answering his question, he raises three important points. First, when he says that we are fragile creatures, he means that we are creature subject to change and chance. Next, he admits that even if we could reduce change and chance by enhancing ourselves, we would not get rid of all fragility. Last, he does not claim that genetic enhancement should never be used to improve humankind.

“Given the apparently enduring desire of humans to enhance their capacities, and given the likelihood that new genetic technologies will at some point enable us to enhance our capacities in significant and perhaps unprecedented ways, now is the time for society to begin thinking about how far it ought to go in this regard” (Parens, 549)

He then warns us about three desires we have as we contemplate using enhancing technologies: we desire to reduce change, we desire to reduce chance, we desire for paradise. Parens raises objections to these three desires. First, before we reduce chance, we need to consider what it might cost us. We might lose the beautiful experiences that change gives us. A plant, as Parens illustrates, is beautiful because it changes as we anticipate the blossoming and then remember its passing. Additionally, we might lose the relationships of care between people that are possible only if change exist. If, for example, everyone stays young, we will lose the relationships between the generations. Finally, we might lose diversity across life span. We might all look the same and act the same.

Second, Parens shows how chance is part of our world and its plays a crucial role. This echoes his earlier points as humans might all become similar if we reduce the chance to which humans are subject in the natural lottery.

Third, he explains that our view concerning enhancement is embedded in our conception of the relationship between humans and the natural world. He notes how those in favor of enhancement have a similar conception of the relationship between the world and humans as that of Francis Bacon. For Bacon, the mission of science was to repair the damage made by the Fall of Man and to restore humans to their original state of glory. However, as Parens states, they are alternative views, in which this relationship differs. For Bacon, nature is ours to master, but for others nature is not ours. Thus, a different perspective on the relationship between nature and humanity would lead to different ideas about how to use enhancing technologies.

He concludes that,

“It would be cruel, if not stupid, to suggest that we ought never to use genetic technology to heal the sick. It probably would be foolish to suggest that technology ought never to be used for the enhancement of human beings. So too would it be foolish to forget that without the desire to control and master the world there would be no desire to control and master ourselves. My suggestion has not been that we should figure out a way to extirpate our desire to control and alter ourselves and the world; rather, it has been simply that we should think more deeply about how attempts at control and alteration that truly enhance life are different from that impoverish it. It may be that thinking more deeply about that difference will entail rethinking some basic beliefs about our proper relationship to ourselves and the rest of nature” (Parens, 552).

For alternative views concerning the stance between humankind and nature see “Scientists and Theologians are Playing God.”

[1]Erik Parens, “The Goodness of Fragility: On the Prospect of Genetic Technologies Aimed at the Enhancement of Human Capacities,” Contemporary Issues in Bioethics, Tom L. Beauchamp and LeRoy Walters, ed.,  6th edition (Wadsworth, 2003), 548-553.

Upcoming conference: Reason, Theology, and the Genome

Upcoming Conference

McDonald Centre for Theology, Ethics & Public Lifea research institute at the University of Oxford presents: A conference on the ethics of human enhancement

What is the place of theology in the growing debate over genetic engineering and human enhancement? Are theological reasons of interest only to believers? Or, as Michael Sandel and Jürgen Habermas have both suggested, might they be important for society generally, for secular and religious alike? Reason, Theology and the Genome brings together a distinguished international panel of speakers, representing many different disciplines and points of view, to consider the relevance of theology to one of the most important questions of our time.

Should Human Beings Have Sex?

Abstract

Author: Robert Sparrow

The American Journal of Bioethics, Volume 10, Issue 7, July 2010

Since the first sex reassignment operations were performed, individual sex has come to be, to some extent at least, a technological artifact. The existence of sperm sorting technology, and of prenatal determination of fetal sex via ultrasound along with the option of termination, means that we now have the power to choose the sex of our children. An influential contemporary line of thought about medical ethics suggests that we should use technology to serve the welfare of individuals and to remove limitations on the opportunities available to them. I argue that, if these are our goals, we may do well to move towards a “post sex” humanity. Until we have the technology to produce genuine hermaphrodites, the most efficient way to do this is to use sex selection technology to ensure that only girl children are born. There are significant restrictions on the opportunities available to men, around gestation, childbirth, and breast-feeding, which will be extremely difficult to overcome via social or technological mechanisms for the foreseeable future. Women also have longer life expectancies than men. Girl babies therefore have a significantly more “open” future than boy babies. Resisting the conclusion that we should ensure that all children are born the same sex will require insisting that sexual difference is natural to human beings and that we should not use technology to reshape humanity beyond certain natural limits. The real concern of my paper, then, is the moral significance of the idea of a normal human body in modern medicine.
Find abstract here and peer commentaries here.

Human Cloning, likely to happen before 2050

Scientific American

According to “12 Events that will change Everything,” an article in the latest issue of Scientific American, the cloning of humans will likely happen before 2050. How likely? This article contemplates “12 possibilities and rate their likelihood of happening by 2050” (36) and use the following scale: Very unlikely, Unlikely, 50-50, Likely, and Almost certain. We shall then prepare ourselves to meet our Mini-Me(s).

The author, Charles Q. Choi, suggests that since the cloning of Dolly, the further step is inevitably the cloning of humans. However, Choi recognizes, like most scientists would, that the procedure is not only more complex with humans, but also raise some ethical concerns. Should we, for example, clone someone without her consent?

Nonetheless, human cloning would have some advantages and new possibilities. A clone might have a better life as she could learn from her old ‘self.’ If someone learns at only 25 that she is talented in music, she could tell her 5 year old clone to take music lessons. Moreover, extinct species like the Neanderthal could be revived.

Finally, Choi recognizes that the ‘yuck’ factor can play a major role in human cloning.  We might find the idea of cloning ourselves disturbing now, the same way we did with IVF.  But in a few years, we might not even think much about it.

“Scientist Infects Himself With a Computer Virus (video)”

The full story here

The creation of chimeras using human genes

“Geoffrey Bourne, former director of the Emory University primate center, once stated that ‘it would be very important scientifically to try to produce an ape-human cross.’ Other researchers have suggested using women as ‘hosts’ for the embryos of chimpanzees or gorillas” (See Francis Fukuyama, Our Posthuman Future, Consequences of the Biotechnology Revolution, 207. )

Neuroscience Boot Camp

neuroscience_bootcamp

Neuroscience Bootcamp

In order to keep up with new medical technologies in neuroscience, I would like to attend this 11 days “Boot Camp” on neuroscience.

“Applications are now being accepted for the 2010 Neuroscience Boot Camp at the University of Pennsylvania.  We are excited about the second annual boot camp, keeping what worked so well this past summer — great teachers, a small but very diverse group of students, and a varied set of teaching methods — and making it even better!”

“Through a combination of lectures, break-out groups, panel discussions and laboratory visits, Boot Camp participants will gain an understanding of the methods of neuroscience and key findings on the cognitive and social-emotional functions of the brain, lifespan development and disorders of brain function.  Like last year’s faculty, the 2010 Boot Camp faculty consists of leaders in the fields of cognitive and affective neuroscience who are committed to the goal of educating non-neuroscientists.”

“Penn’s Neuroscience Boot Camp has been endorsed by the Neuroethics Society as a way for non-neuroscientists to gain a better understanding of the science behind the proliferation of new “neurofields” including neuroethics.”

The deadline for admission and scholarship is February 1st. I will give it a try!

Did Plato foresee the ethical challenges of enhancement?

In To Relieve the Human Condition, Gerald McKenny starts his book with the following sentences: plato4

In Book III of the Republic, while discussing the training for the guardians of his ideal city, Plato addresses the role of medicine in their formation. His underlying question is how the pursuit of health can be so managed that medicine serves rather than hinders or dominates our moral projects. This question in turn breaks down into several more specific questions: How much attention or vigilance should we devote to our bodies in the effort to optimize their capacities? How much control should we allow physicians to exercise over our bodies? What ends, individual and collective, should determine what counts as a sufficiently healthy body? What limits should we observe in our efforts to improve our bodily performance and remove causes of suffering (Plato, 403c-407a)? [1]

Those same questions need to be asked again in the debate concerning human enhancement. Should we, for example, use genes from other animals in order to improve our performances? Consider the following excerpt from Julian Savulescu in Human Enhancement:

It has been possible since about 1980s to transfer genes taken from one species into another. ANDi is a rhesus who has had a jellyfish gene incorporated into his DNA. This results in a unique fluorescent green glow. Alba is a genetically engineered rabbit created by French scientists for artist Eduardo Kac. She also has a fluorescent glow. These transgenic animals show that a gene from one species can be successfully transferred and activated in a completely different genome in a different species. There is no reason why genes from other species could not be transferred to human beings, creating transgenic humans. [2] (For more little green animals see http://timesonline.typepad.com/science/2009/05/the-sciencecentral-glowing-animals-gallery.html )

glow_monkeySavulescu continues, “Transgenesis could be used to introduce genes coding for superior physical abilities from other animals. For example, humans could have the hearing of dogs, the visual acuity of hawks, the night vision of owls, or even be able to navigate by sonar employed bats.” [3] It seems, therefore, that Plato’s question needs to be asked once again: “What limits should we observe in our efforts to improve our bodily performance and remove causes of suffering?” We may also consider that if we are able to do something, it does not mean that we should do it.


[1] Gerald P. McKenny, To Relieve the Human Condition, Bioethics, Technology, and the Body (Albany, NY: State University of New York Press, 1997).

[2] Savulescu, Julian and Nick Bostrom, ed. Human Enhancement (Oxford University Press, 2009),212.

[3] Ibid, 213.

“Toward a More Fruitful Debate About Enhancement,” Review

framework4

Toward A More Fruitful Debate

In this essay, Erik Parens wants to “illuminate the structure of the debate” in neuroethics, particularly in the issues

human_enhancement

related with “the enhancement of human traits and capacities” (181). He rightly thinks that if “we get better at noticing the structure of the debate about enhancement, we might engage in a more fruitful debate” (180). He points out three important issues.

First, he shows how critics and proponents of enhancement technology both seek to be authentic human beings. He states, “[M]any in fact are striving to live up to the moral ideal of authenticity. Whether or not they achieve it, they aspire to find self-fulfillment and to become who they really are” (182). Unfortunately, critics and proponent differ in their understanding of authenticity. He writes, “[T]he knockers and boosters –or critics and proponents–of ‘enhancement technologies’ share the moral ideal of authenticity, but they understand authenticity differently: they have different views about what it consists in, and thus about how to achieve it” (183). For the critics, enhancement can be a threat to who we really are. They would worry that “mood-alternating drugs will separate us from the actions and experiences that normally accompany those moods . . . we will be separated from who we really are and from how the world really is” (184). On the other hand, for the proponents, enhancement can help us be more authentic. They sees enhancement not as “a threat to authenticity, but rather as tools that can facilitate our authentic efforts at self-discovery and self-creation” (186).This disagreement about authenticity comes from a disagreement raised by two different frameworks used to look at the world, which Parens analyses in the second part of his essay.

Second, he looks at the two different frameworks used by critics and proponents. This section echoes one of his earlier essays. In “Creativity, gratitude, and the enhancement debate” and in this essay, Parens distinguishes between two philosophical/ethical frameworks that “people seem to come to the academic debate about enhancement technologies.” The first framework desires “to mend and transform ourselves and the world.” Because of this desire to create and change creation, Parens names this framework: Creativity. The second framework takes a different approach. It reminds us that we are not creators and that life is a gift. This view, which he calls Gratitude, tends to let nature be. He writes, “According to Genesis, and it seems to me much of Judaism, our responsibility is not merely to be grateful and remember that we are not the creators of the whole. It is also our responsibility to use our creativity to mend and transform ourselves and the world. As far as I can tell, Genesis and Judaism do not exhort us to choose between gratitude and creativity. Rather . . . it is our job to figure out how to maintain that fertile tension, making sure that neither stance gets more than its share” (189).

Third, Parens discusses two cases to illustrate how critics and proponents can learn from each other. He discusses a problem for an honest proponent and then for an honest critic. First, he demonstrates that in some cases a pill (or enhancement) might not foster authenticity, but hinders it. He points out the example of the creation of a pill who could engender the “perception of intimacy” in order to encourage a woman to experience the desire for sexual intercourse. He rightly thinks that “honest proponents will acknowledge that the idea of a pill that would, in the absence of genuine intimacy, create the perception of intimacy is perplexing” (193). Indeed, the person taking this pill would not live truly or authentically. Second, he demonstrates how, in some cases, enhancement might help someone to become who she/he truly is. He gives the examples of transgenders, to whom surgeries enable them to change their anatomies in order to become more authentic. He writes, “Different from the ‘pill of intimacy,’ which undermines the purpose of achieving genuine intimacy and relationship, [transgender]’s surgeries seem to promote that purpose” (195).

Parens is really helpful in distinguishing both frameworks used in the enhancement debate in neuroethics. Instead of focusing on major differences they might have, he tries to make them work together. He argues that the biblical story and Judaism contains both frameworks. He acknowledges that “it is our job to figure out how to maintain that fertile tension” between Creativity and Gratitude (189). Unfortunately, he does not reflect on how we could have those two frameworks working together. It would be helpful to understand the cultural mandate in order to understand in what ways humans are allowed or able to alter nature. Furthermore, the Fall has not only affected human creativity but has also forced us to be innovative in order to fight sickness and diseases. One will need to take this in consideration in order to make those two frameworks work together.

Parens is also right in pointing out that both critics and proponents seek to become authentic human beings. The idea of authenticity raises some problems which religious people and theologians have struggle with for a long time. As Sandel writes in The Case Against Perfection, “To grapple with the ethics of enhancement, we need to confront question largely lost from view in the modern world–question about the moral status of nature, and about the proper stance of human beings towards the world. Since these questions verge on theology, modern philosophers and political theorist tend to shrink from them. But our new powers of biotechnology make the unavoidable” (Sandel, 9). I suppose religious people also desire to become authentic human beings, but differ about what is authenticity and how one should achieve it. One may wonder if someone should be encouraged to take an enhancer in order to become fully human.

The age of enhancement

The age of enhancement

The age of enhancement

Here is a great article I read this morning about “a cornucopia of drugs [that] will soon be on sale to improve everything from our memories to our trust in others.”

While a lot of the promises for a better world seem attractive, I wonder if our quest to master our own body and brain will produce some side effects that are still unseen. One can think of how the human quest to master nature has brought us in a big environmental mess. I think that neuroethics could probably learn a lot from environmental ethics. It seems that the question, “How far should we be able to modify our environment?” reflects the question, “How far should we be able to modify ourselves?”

Video Choice

Eugenics: War on the Weak

Random Quote

“It is difficult, for me at least, to see any powerful principled reasons to remain human if we can create creatures, or evolve into creatures, fundamentally "better" than ourselves.”
by John Harris Enhancing Evolution, 40

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